Brainomix 360 e-Lung: Vision to Precision

Brainomix e-Lung is an FDA-cleared, AI-powered imaging software platform that automatically identifies and quantifies features on CT lung scans enabling clinicians to more easily identify changes including subtle deteriorations over multiple scan timepoints.

 

Patients with ILD can develop Progressive Pulmonary Fibrosis (PPF), which causes irreversible lung damage and leads to early mortality. The key to the best outcome and survival for patients is early initiation of treatment. However, identifying patients eligible for treatment based on imaging can be challenging, even for experts.

E Lung In Clinical Setting

Researchers Demonstrate Earlier Detection of PPF in New Study

Results from REVISE PPF -  a retrospective research study conducted with the University of Chicago, Weill Cornell Medical, and the University of Alabama at Birmingham -  have been presented at the European Respiratory Society (ERS) Congress and the CHEST Annual Meeting in 2025. Using imaging features extracted with e-Lung, the authors showed:

  • They could identify CT progression in 74% of patients deemed clinically stable.
  • They accurately identified patients at risk of developing future PPF from a single baseline scan.
  • Imaging metrics on the first patient scan are robust, independent predictors of mortality.

Transforming Pulmonary Fibrosis Care

AI-powered CT analysis has the potential to transform pulmonary fibrosis care. With it, doctors can enhance early detection, precisely quantify disease, and track progression over time.

"The data we have shown for e-Lung is very promising, and the ability to objectively assess parenchymal changes to predict disease trajectory and treatment responses could really help us personalize treatment decisions and improve outcomes for patients living with pulmonary fibrosis," said Dr Teja Kulkarni, Associate Professor and Director of the ILD Program at the University of Alabama at Birmingham.

2B

Validated by the INBUILD Trial

Through a research collaboration and partnership with Boehringer Ingelheim, the global leader in pulmonary fibrosis therapies, Brainomix were granted privileged access to the landmark INBUILD clinical trial dataset to run the first quantitative CT analysis.

The analysis used quantitative CT measurements. These measurements were used by the authors to accurately and sensitively facilitate identification of PPF, and establish the value of quantitative metrics as a prognostic tool for the assessment of PPF progression.

“The technology [e-Lung] may help in monitoring disease progression and tailoring treatment plans to patients individually. This will ultimately improve outcomes and quality of life for those affected,” Martin Beck, Therapeutic Area Head for Inflammation, Boehringer Ingelheim.

Click here to read more of Martin's interview.

3A

New e-Lung Reader Study

A new e-Lung reader study was presented at ECR 2026 by Dr Logan Sun (Royal Brompton Hospital, London).

Five readers, blinded to clinical data, independently reviewed serial CTs side-by-side from 102 patients with non-IPF fibrotic ILD. All patients in this cohort demonstrated marginal FVC decline of 5 - 10%.

Readers categorized each case as either stable or progressive disease based on visually estimated changes in ILD extent. e-Lung overlays were applied to cases initially categorized as stable but with a quantitative CT-flagged increase in fibrotic extent, enabling readers to either retain the original categorization or change to progressive.

The quantitative CT imaging features were used to identify 22 to 40 cases per reader for re-evaluation, leading to readers changing PPF categorization in up to 94% of these cases, demonstrating improved reader performance.

Studies have explored a novel configuration of density and volume parameters, the Weighted Reticular Vascular Score (WRVS), which characterizes the total extent of peripheral fibrosis.

WRVS is a strong predictor of FVC decline in IPF patients.

(Devaraj A, AJRCCM May 2024)

An increase in WRVS is linked to greater risk of mortality.

(George PM, ERJ Open Res Dec 2024)

A change in WRVS of 3% was a more accurate predictor of mortality compared with FVC decline or radiologically-defined progression.

(George PM, ERJ Open Res Dec 2024)

Hear from our valued partners and collaborators

Contact us today

Speak with us to learn how to integrate our ILD biomarkers into your clinical trials and clinical research.

Collaborating and Innovating with our Partners